ElectroNanoBio

The team interest covers electrochemistry, modeling, micro-/nanosystems with a strong emphasis on biologically oriented questions. The following list provides a brief overview of several representative research directions.

Enhanced analytical devices

• We develop miniaturized down to nanoscale electroanalytical devices for their increased performances, decreased amounts of samples and co-reactants with portable instrumentation.
• Microelectrode arrays in confined systems for catalysis and durability. Properties of microelectrodes are investigated both theoretically and experimentally in particular conditions controlled by hydrodynamics and space confinement (microchannel electrodes, circulating droplets).
• Boosting (electro)analytical performance with modeling to optimize electrocatalytic materials i.e. to concentrate analytes at the nanoscale level by physical or chemical adsorption, boost electron transfer rates and increase selectivity.
• Coupling electrochemistry and spectroscopy for electroanalysis. We use electrochemistry as a driving force of the analytical detection and spectroscopy to detect and quantify the analyte for the direct uncoupling of signal (photons) and noise (potential).

New looks at biological processes

• Measuring and modeling for exocytosis: theoretical modeling and quantitative analysis of kinetic amperometric data from neurons (intrasynaptic) and endocrine cells and their confrontation to theory, amperometry and optical measurements.
• Deciphering oxidative stress with electrodes: implementation of cell culture in microfluidic systems integrating electrochemical sensors.

Modeling electrochemical systems

• Modeling and statistical characterization of systems with randomly distributed active sites.
• Modeling systems involving adsorption-coupled electron transfer (concerted/non- concerted pathways).
• Modeling of generator-collector electrochemical devices.
• Modeling of nanoscale sampling of organelles and vesicles with nanopipettes from cells and tissues.