While present at relatively low concentrations compared to organic species, endogenous metals are involved as cellular actuators such as enzymes or transcription factors. Their tight regulation at the cellular and organism levels is required in many biological processes, ranging from physiological to pathological ones.

We develop and implement innovative and non-conventional approaches to achieve metal quantification, localisation and bioavailability in a variety of biological models and physiopathological contexts. Our projects cover elemental metal detection particularly to improve sample preparation procedures, together with genetically-encoded systems to sense metal levels inside biological samples.

Collaborators:

• O. Espeli & S. Rimski, Collège de France, Paris
• P. Bost, Institut Curie, Paris.