Re(CO)3 complexes are developed as multimodal probes to correlate fluorescence, IR-imaging and X-fluorescence imaging. These probes are easy to conjugate to any type of biomolecule that can be imaged both by IR, possibly with subcellular resolution, using near-field detection (nano-IR, AFM-IR), and by X-fluorescence.

We have developed and validated a series of Re-based complexes accumulating in various organelles and that can be used as organelle trackers in non-conventional imaging techniques such as X-fluorescence imaging or IR-based imaging techniques.

List of the Re-based trackers so far available: nucleus trackers, mitochondria, Golgi apparatus.

Collaborators:

• C. Sandt, Synchrotron SOLEIL, St Aubin
• K. Medjoubi, A. Somogyi, Synchrotron SOLEIL, St Aubin
• C. Aimé, CPCV, Paris
• A. Deniset & A. Dazzi, ICP, Saclay
• M. Coogan, Univ. Lancaster, UK
• O. Espeli, Collège de France, Paris

References: 14 S. Clède and C. Policar, Chem. Eur. J., 2015, 21, 942–958. 15 C. Policar et al., C.R. Chim., 2024, 27, 1–25. 16 S. Hostachy et al., Chem. Sci., 2018, 9, 4483–4487. 17 S. Clède et al., Chem. Commun., 2015, 51, 2687–2689. 18 C. Policar et al., Angew. Chem. Int. Ed., 2011, 50, 860–864. 19 G. Schanne et al., Inorg. Chem. Front., 2021, 8, 3905–3915. 20 S. Clède et al., Chem. Commun., 2012, 48, 7729–7731.