In our research group we use the alphaproteobacterium model Caulobacter crescentus to understand how bacterial cell wall and cell envelope metabolisms are genetically and functionally coordinated with cell cycle and bacterial cell pole differentiation. Indeed, C. cresentus displays an atypical asymmetric division resulting in two different daughter cells: a motile non-dividing swarmer cell and a sessile replicative stalked cell. Each of these daughter cells harbors functionalized cell pole with either a flagellum and pili or a stalk. By combining genetics, biochemical studies, and microscopy, we mainly focus on peptidoglycan metabolism which includes its synthesis, remodeling and recycling and how it is integrated to C. crescentus cell cycle.