The objective of this research theme is the rational design and vectorization of bioactive molecules by transport and/or targeting molecules. One of the approaches aims at the chemical modification of homeoproteins of therapeutic interest or the functionalization of nanobodies or nanoparticles (gold, iron oxide and liposomes) by biomolecules (AMP, CPP, MTP, targeting peptide, protein, …) for the development of multifunctional platforms for vectorization, imaging, diagnosis and therapy.

Another project aims to design caging strategies for the specific release of bioactive compounds into diseased cells. For example, the use of self-immolating bonds in the presence of -galactosidase is applied to the development of novel senolytic compounds.

Photo-cleavable amino acid protective groups are developed for the design of spatio-temporally activated peptide prodrugs within cells.

Associated methodologies:

• Functionalization of nanoparticles (F. Burlina, C. Mansuy, R. Moumné, A. Walrant)
• Protein vectorization (F. Burlina, S. Sagan, A. Walrant)
• Organic synthesis (R. Moumné)