Consortium of experimental platforms in Chemistry, Physics and Biology at PSL University for the preparation and characterization of systems from the molecule to nanometric devices and living systems.

This project complements the equipment acquired in the frame of the Equipex IMF-NMR project by co-funding the purchase of two cryogenic probes on the 900 MHz spectrometer, optimized for proton and carbon-13 detection.

This project aims at investigating fundamental aspects of nonlinear magnetization dynamics of hyperpolarized spins by Dynamic Nuclear Polarization (DNP) in high magnetic fields at liquid Helium temperatures using an electronically controlled NMR maser.

Enzymatic activity is at the heart of the metabolic function of cells, with the regulation of numerous metabolic pathways essential for maintaining cellular homeostasis. This project aims to make dDNP a robust technique for monitoring enzymatic reactions and to implement these developments for studying enzymatic reactions under physiological conditions.

Assess the potential use of recently developed NMR techniques for kinetic analysis of CO2 release by monoethanolamine solutions in CO2 capture.

Development of an ultra-low-temperature DNP setup to probe ultra-wideline nuclei at 800 MHz and solve poor NMR sensitivity issues by performing DNP at high fields.

The project aims to extend dynamic nuclear polarization (DNP) to high magnetic fields and near ambient temperatures using Electron Nuclear Magnetic Resonance (ENMR) and high power pulsed microwave technology.

Development of photo-CIDNP methodologies to hyperpolarize long-lived states and explore applications in high-throughput drug screening.

Novel applications of photo-CIDNP in drug discovery and structural modeling of protein-ligand complexes.

Investigating how molecular dynamics affects allosteric enzyme activation using experimental and computational methods.

Understanding the organization, dynamics and mechanics of NHEJ DNA repair condensates and their regulatory interactions.